Expression And Significance Of Cox-2 And Bcl-2 In Cervical Lesions

Objective: To detect the expression of cyclooxygenase-2 (cox-2) and bcl-2 in cervical leisions and to study the association of cox-2 and bcl-2 in cervical intraepithelial neoplasia (CIN) and cervical cancer.Methods: Cox-2 protein and bcl-2 protein were examined immunohistochemically in one hundred and thirty-five cervical specimens, consisting of normal cervical epithelium (n=15), chronic cervicitis (n=15), cervical intraepithelial neoplasia lesions (n=45) and cervical cancer samples (n=60).Results: (1) The expression of cox-2 was most found in the cytosol. The positive ratio of cox-2 in chronic cervicitis, cervical intraepithelial neoplasia and cervical cancer samples were respectively 40.00% (6/15), 44.44% (20/45 ), 86.67% (52/60), differed from the negligible expression found in normal cervical tissues.The expression of cox-2 in cervical tissues was significantly increased compared to chronic cervicitis and cervical intraepithelial neoplasia (CIN) (p<0.001, P<0.001, P<0.001) ; There was no significant difference of cox-2 expression between cervical intraepithelial neoplasia and chronic cervicitis. The level of cox-2 expression was higher in both cervical intraepithelial neoplasia and chronic cervicitis than in the normal cervical tissues (p=0.004, p=0.002).(2) The expression of bcl-2 was most found in the cytosol. The positive ratio innormal cervical tissues,chronic cervicitis, cervical intraepithelial neoplasia and cervicalcancer samples was 6.67% (1/15), 13.33% (2/15), 46.67% (21/45), 83.33%(50/60) .The expression of cox-2 was significantly increased in both cervicalintraepithelial neoplasia and cervical cancer samples compared with normal cervical...