The Dysfunction Of Macrophage Phagocytosis In Patients With Spontaneous Rupture Of Hepatocellular Carcinoma

Object: The purpose of this study is to examine phagocytic of macrophage; furthermore investigate the mechanism relate to spontaneous rupture of hepatocellular carcinoma (HCC). Method: In this study, we use to look-forward experimentation trial to collect from 9 patients with spontaneous ruptured HCC and 9 patients with non-ruptured HCC. Tumor tissue specimens of patient chooded of post-operation non-haemorrhage putrescence is used to examine: quantificationally investigate to expressions of hepatic macrophage phagocytic function and its CD11b, CD18 and CD16 of surface receptors in flowcytometry; qualitatively analysis to locations and distributions of hepatic macrophage (CD68) in immunohistochemical analysis (streptavidin-biotin peroxidase method). Results: Quantificationally investigate to phagocytic function of hepatic macrophage in flowcytometry from cases with spontaneous ruptured HCC and non-ruptured HCC. ① phagocytic permil (phagocytic microsphere) of hepatic macrophage from liver carcinoma tissures is lesser cases with adjacent non-carcinoma tissures in groups spontaneous ruptured HCC, with statistical significance [4.34% (2.85, 6.82‰) vs 7.7‰(4.31, 8.80‰), P<0.05]; ②phagocytic permil of hepatic macrophage from groups with spontaneous ruptured HCC is lesser cases with non-ruptured HCC in adjacent non-carcinoma tissures markedly, with statistical significance[7.70‰ (4.31, 8.80‰) vs 10.92‰ (8.46, 15.54‰), P<0.05]; (3) phagocytic permil of hepatic macrophage from liver...