Dynamic Observation Of The Antiangiogenic Effect Of Cyclophosphamide On Lewis Lung Carcinoma Model

Background and ObjectivesToday as compared to before, chemotherapy is the mainstay therapy for many malignant tumors. As per the traditional belief, the proliferating tumor cells were thought to be the chemotherapy target. The continuous growth and metastasis of tumor depend on angiogenesis, as was first proposed by Folkman in 1971. From then on, the anti-angiogenic therapy of tumor has been the focus of research. Further, researches have shown that many chemotherapy drugs also have anti-angiogenic effect. Chemotherapy drugs can also damage tumor blood supply by killing or inhibiting activated endothelial cells in tumor bed, at the same time of killing multitude tumor cells.It is well known that the angiogenesis of tumor is mediated by both angiogenesis promoters and angiogenesis inhibitors. Among them, the vascular endothelial cell growth factor (VEGF) is one of the strongest promoters. In the embryonic stages, the dynamic change of VEGF is related with the growth and maturation of the vasculature. So we doubt that whether there are changes in VEGF levels during the repair of vascular system after different modes of administration of chemotherapy? If there are, then, whether these changes in VEGF levels are correlated with the changes of vascular supply to the tumor?It has been confirmed that metronomic chemotherapy inhibited tumor angiogenesis significantly. The damage to the vessels after metronomic chemotherapy...