| Backgroud and ObjectivesAccording to the data from WHO in 1997, there were 135 million people in the whole habitable globe diagnosed to diabetes, expected to increase to 299 million in 2025.Type 2 diabetes mellitus accounts for about 90%. 80% of patients died from diabetes had atherosis, 75% of which have atherosis of coronary artery.Adipose tissue was not only considered as a storage site for fat, but also a complex metabolic and endocrine organ. When it was stimulated, the adipose tissue can secrete many kinds of proteins adjusting the balance of metabolism, including tumor necrosis factor (TNF-a), leptin and adiponectin. Adiponectin, first described as Acrp30 (adipocyte complement related protein of 30 kDa), and also termed AdipoQ, Apml and GBP-28, was an adipokine that was secreted specifically from adipocytes. Adiponectin gene was located in 3q27. The present study had shown that adiponectin was related to insulin resistance, and there was growing evidence that adiponectin had a protective effect against atherosclerosis, due to anti-inflammatory and antiatherogenic features.Tumor necrosis factor-alpha (TNF-a), was a multifunctional cell factor, the molecular weight was 17kd, initially separated from macrophages. In recent years, scientists found that adipose tissue and skeletal muscle had the potential of secretion and synthesization of TNF-a, which played a very important role in the pathological...
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