Treatment For AD Rats With Lingcao Oral Liquid And Its Mechanism

Background and PurposeAlzheimer's disease (AD), characterized clinically by progressive loss of memory and cognition, pathologically by senile plaques (SP), neurofibrillary tangles (NFT), and synapse loss, is an age-related neurodegenerative disorder. The primary pathogeny and cause of AD remains unknown. The morbidity of AD is high among the elderly. In developed countries, AD has already been the fourth cause of death after heart disease, cancer and stroke. For lack of effective early diagnostic and therapeutic methods, it's very important and urgent to actively study the drug for AD's treatment.The nucleus basalis of Meynert (nbM) locates in the base of the forebrain. Most neurons in nbM are cholinergic neuron. Neurofibers sending out from nbM project into hippocampus, cerebral cortex and other brain regions. Ibotenic acid (IBO) is a kind of N-methyl-D-Aspartic acid (NMDA) receptor agonist with strong excitatory neurotoxin. It can damage the learning and memorial ability of the rat eternally and steadily. The ideal animal model can be made by injecting IBO into the nbM of the rat.It is extremely significant to look for the effective drug being used for treating AD from the traditional medicine. Lingcao oral liquid mostly consists of Ganoderma lucidum and Cordyceps sinensis and contains a variety of amino acids, polysaccharides, alkaloids and trace elements. China has a long history in the use of Ganoderma lucidum and Cordyceps sinensis in medicine. Mythic fungus and Cordyceps sinensis have extensive pharmacologic activity, for example, enhancing immunity function of the body, removal of free radicals and preventing their peroxidative effects on unsaturated...