| The incidence, lethality and mutilation of traumatic brain injury (TBI) are going up with the development of our society, TBI is even one of the main affections threatening mankind health. Nowadays, it is still necessary to study the mechanisms of TBI though the cure rate of it has been increased. Microglias are distributed extensively in central nervous system (CNS),They take an important role in physiologic function of neuron, for example, supporting, nutrition, protection and reparation function of neuron.They are also one of obbligato elements in CNS. The study on microglias in the CNS diseases, such as inflammation, epilepsy,Parkinson's disease and ischemia,has been carried out extensively. Whereas, there were few researches on microglias in TBI recently. Whether did microglias response to the stimulation of TBI? What was the characteristic of activated microglias in impaired brain tissue? How did the activated microglias change its shape and time course? These haven't been reported lately. Accordingly,It's helpful to study the relation between microglias and TBI. We should make full use of the protection of microglias and reduce its damage as far as possible in order to increase the cure rate of TBI.Resveratrol, a polyphenolic compound which is abundantly present in the seeds and skin of grapes, hellebores and giant knotweed rhizomes, has various biologic activities, such as anti-platelet activity, anti-inflammatory activity, anti-carcinogenic activity etc. It also acts as free radical scavenger and antioxidant and has cardiovascular protective effects. In recent years, the... |
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