| BackgroundThe pathological process of chronical overexposure to manganese is selective degeneration of dopaminergic cell in substantia striatal system, which leads to dopamine deficiency. Experiments in vivo and vitro implicated that manganese is a sort of dopaminergic neurotoxicant causing PD related neuron degradation disease.α-SYN is a 140-amino acid protein, was originally isolated from cholinergic vesicle preparations of the electric organ of the ray Torpedo californica in 1988 by Maroteaux. which is highly conserved among vertebrates and was identified in humans as the precursor of the non-A beta component of disease amyloid (NACP). Since the discovery of its possible implication in the pathophysiology of neurodegenerative disorders, α-SYN has been the subject of an increasing number of studies aiming at elucidating its physiological function and its possible interactions with other proteins.The function of α-SYN is still unknown, several studies suggest that it plays an...
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