Changes Of Peripheral Blood Levels Of MMP-9 In Patients With Coronary Artery Disease And Effects Of Atorvastatin On The Proliferation Of Rat Aorta SMCs And Activity Of MMP-9 Secreted By Rat Aorta SMCs

Background With the improvement of living,Coronary Heart Disease (CHD) has become one of the common diseases to harm people's health and cause people death. Atherosclerosis (AS) is the main reason of CHD. Therefore, it's getting important to precaution, early diagnose ,treat and even reverse the AS. In the pathogenesis of AS, that vascular smooth muscle cells(VSMCs) permeate interior elastic layer and arrive at vascular Intima and proliferate is the central event .But the mechanisms of migration and proliferation of SMCs are not clear now . Restenosis (RS) after percutaneous coronary intervention (PCI) is the main complication of interventional therapy of CHD.And the migration and proliferation of SMCs are the most characteristic cytobiology events in AS.Recently people found that SMCs synthesize and secrete extracellular matrix (ECM) and matrix...