The Effect And Mechanism Of ZBPY Decoction To Dendritic Spines In Damaged Neurons Of Glutamate

Synapse is the important structure for transmission between neurons. The dysfunction and loss of synapse will destroy the function of nervous system greatly. Synapse loss is one of the most important pathological changes of Alzheimer's disease (AD). Synaptic dysfunction and failure are processes that occur early in AD, it is the best current pathologic correlate of cognitive decline. Dendritic spines are some small protrusions from the dendrites of the principal neurons in mammalian. Dendritic spines represent the postsynaptic component of most excitatory synapses. Spines are the main sites of excitatory synaptic transmission in central nervous system. Synaptic transmission is thought to be the physiological basis of learning and memory. Hundreds of molecules have been identified in the PSD: receptors, cytoskeletal proteins, scaffolding proteins, and signal proteins who are in charge of the density and shape of dendritic spines. Spine-associated Rap guanosine triphosphatase (GTPase) activating protein (SPAR) is an important candidate for mediating activity-dependent remodeling of synapses. And is critically involved in spine maturity, especially in the mature spine formation and the maintenance of spine maturity. Serum-inducible kinase (SNK), one of the polo-like kinases, induced by synaptic activity and was targeted to dendritic spines, eliminates SPAR protein, and causes loss of mature dendritic spines and synapses. The previous studies of our group suggested that Zi-Bu-Pi-Yin decoction (ZBPY) has notable functions of against aging such as anti-oxidation, improve the ability of study and memory. Therefore we want to make it clear that the molecular mechanism of ZBPY for preserving the structure and function of synapses, especially the...