| Objective: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by irreversible, progressive loss of memory followed by complete dementia, is the fourth largest cause of death for people over the age of 65 years."Slow or indirect excitotoxicity"mechanism plays an important role in the pathogenesis of this illness, although this disturbance is probably a secondary phenomenon to other neurochemical, genetic or metabolic changes, essential to the development of AD. ZBPY decoction pretreatment administration has significant protective effect on excitototic injury of hippocampal neurons, the protective effect related to the regulation of cholesterol homeostasis in neurons. 90% excitatory glutamatergic postsynaptic parts in the brain are located on dendritic spines. Spines are small protrusions on dendritic shafts that reconstitute the primary loci of excitatory synaptic transmission in the mammalian CNS. And synaptic transmission is thought to represent the physiological basis of learning and memory. Hundreds of molecules have been identified in the postsynaptic density (PSD): receptors, cytoskeletal proteins, scaffolding proteins, and signal proteins who are in charge of the density and shape of dendritic spines. Spine-associated Rap guanosine triphosphatase (GTPase) activating protein (SPAR), with its postsynaptic location in the N-methyl-D-aspartate (NMDA) receptor–PSD-95 complex, SPAR is an important candidate for mediating activity-dependent remodeling of synapses, and is critically involved in spine maturity, especially in the mature spine formation and the maintenance of spine maturity. Serum-inducible kinase (SNK), one of the polo-like kinases, induced by... |
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