The Effect Of Corticotomy For Alveolar Remodeling In Rat Orthodontic Tooth Movement

Background:Malocclusion is the one of the three major stomatological diseases which confirmed by WHO(The World Health Organization) and affects physical and psychological health seriously.By traditional technique,the general rate of orthodontic tooth movement was 1mm/month.Therefore,the process of orthtdontic treatment was usually about 2 years or longer.Beacause of these,scholars all over the world focused how to accelerate the tooth movement and shorten treatment period.Recently,they proposed some new methods to accelerate the tooth movenent based on the same principal.Such as:selected the force and timing,reducing resistance of periodontal tissue,local stimulation by electromagnetic force and using medications etc.Corticotomy was used in the orthodontic treatment in the last century,and confirmed that it could accelerate the tooth movement.We presume the reason was Regional Acceleratory Phenomenon (RAP).Following surgical wounding of cortical bone,RAP potentiates tissue reorganization and healing by way of a transient burst of localized hard and soft tissue remodeling.Currently,there only few reports which establishing animal experimental models for molecular biology mechanism study have been pubilshed.It is necessary to investigate the difference between new and traditional technique .Beause of the important role of bone remodeling,we choose TGF-β1 and BMP-2 represent the change of bone remodeling.Objective:This study will set up corticotomy experimental animal models firstly.Evaluating the BMP-2 and TGF-β1 expressions in the periodontal tissue remodeling after corticotomy, researching the mechanism ,building the animal model and providing the new evidences...