Influence Of Polymorphism In Interleukin 1 On Susceptibility Of Ankylosing Spondylitis

Background:ankylosing spondylitis (AS) is a chronic, inflammatory rheumatic disease of the axial skeleton, affecting sacroiliac joints and the spine, commonly to adolescent, with strong family predisposition. It is one of the most common causes of inflammatory arthritis after rheumatoid arthritis. The presence of sacroiliitis is its hallmark. Hip and shoulder joints, and less commonly, peripheral joints or extra-articular structures may also be involved. The etiology of AS is not fully understood, but there is a strong genetic predisposition associated with the histocompatibility antigen, especially HLA-B27. The results of genome-wide scanning, linkage and association analysis indicate that there are some other predisposing genes closely related with AS inside or outside human leucocyte antigen (HLA) area besides HLA-B27. Interleukin 1 (IL-1) plays an important role in the regulation of the immune response, and has high expression in the blood and tissue of many autoimmune diseases. Recently it has been shown that IL-1 is related with some autoimmune disease, such as systemic lupus erythematosus (SLE) and ulcerative colitis, suggesting that IL-1 has some effects in the diseases linked with MHC. As such, its importance has been...