Studies On Dose-Effects Of Ginkgolide B On Severe Acute Pancreatitis And Its Effects On PAF-R Of Pancreas

Ginkgolide B (BN52021) is a competitive antagonist of platelet activating factor receptor (PAF-R). It is one terpenoid extract of Ginkgo biloba leavies. Recent studies have shown that it exerts its effects on severe acute pancreatitis (SAP), but little is known about its molecular mechanism in details; Different dose were applied to treating with SAP. It was studied that the dose-effect of BN52021 on rats with SAP and effects on PAF-R of pancreas. 1 The dose-effect of BN52021 on rats with SAPThe rats were divided randomly into 8 groups: normal control(NC); sham operation(SO); SAP model; SAP+BN52021 1mg/kg; SAP+BN52021 2.5mg/kg; SAP+BN52021 5mg/kg; SAP+BN52021 10mg/kg; SAP+Sandostatin 20μg/kg. 5% Sodium taurocholate was injected conversely into the common biliopancreatic duct in rat to induce the model of SAP: 0.1 ml/kg, 0.1ml/min (using micropump); 15 min after the model, lmg/kg, 2.5mg/kg, 5mg/kg, 10mg/kg BN52021 were respectively injected into rats' femoral vein of different dose groups. 6h after SAP, 2.5mg/kg, 5mg/kg, 10mg/kg BN52021 can decrease the activity of amylase, PLA₂ in plasma, and...