Protective Effect Of Clinical Dose Propofol On Pulmonary Injury In Patients Undergoing Cardiac Valve Replacement

Objective:Lungs have been thought as anti-ischemia organ, because lungs have systemic and pulmonary circulation to supply blood. With cardiopulmonary bypass (CPB) and lung implantation technique fast developing, many experiments and clinical researches show lung existing ischemia/reperfusion(I/R)injury. During the operation of cardiac valve replacement, pulmonary artery can not supply blood to lungs. Meanwhile regional hypothermia can not be carried out in the lung to diminish tissue consuming oxygen. Bronchial artery is the only blood-supply pathway in the lung during CPB, but it mainly distributes bronchial membrane externa. By now, it has not been proved that pulmonary artery has ramus communicans. For there reasons, lungs are in the state of"megatemperature and hypoxia". After regaining blood flow, lungs may be caused to I/R injury. In addition, systemic inflammatory response syndrome is one of the main mechanisms of lung injury, which is received by many scholars at present. With gradually lucubrating on propofol, it is found that the clinical dose of propofol has antioxidation effects and significantly anti-inflammatory.