Serum Levels Of Bone Alkaline Phosphatase And Osteocalcin In Children And Adolescents And The Different Gender

Objective: The levels of bone alkaline phosphatase (BAP) and osteocalcin (OC), which were bone formation markers, were helpful to investigate bone growth of healthy children and adolescents. It would offer foundations for the investigation of bone turnover in children in health and disease through determining the serum concentrations of bone formation markers and analyzing the relationships between each of them and with sex and age.Methods: Blood samples were taken from 320 healthy children (193 boys and 127 girls) to assess serum BAP, OC, and total alkaline phosphatase (TAP). Just before the samples were collected, the children's body weight and body height were measured and the body mass index were calculated, and the sex and age were recorded. Serum BAP, OC and TAP were determined by using Enzyme-Linked Immunosorbent Assay (ELISA). The levels of serum BAP and OC were analyzed by the biological groups and age-related changes. The data were analyzed with SPSS for Windows 11.5 statistic software and presented by mean (X) and standard deviation (SD). The Student-Newman-Keuls and the independent-sample t test were...