| Objective: Hepatic fibrosis is the outcome of gradually pathological changes for all kinds of hepatic disease, which is very harmful to human health. The main character of the diseases is the deposition of extra-cellular matrix (ECM) because of its excess synthesis and decreased degradation. The formation of hepatic cirrhosis is a complicated process in which multi-factor and multi-cell involved. Among them the cell factor net is the key point in most recent studies. Connective tissue growth factor (CTGF) which is newly discovered is regarded as the lower reaction element of the TGF-β1, functioning as to accelerate proliferation of fibrous cells, and to participate the production and accumulation of ECM. The important role of activation of hepatic stellate cells in pathogenetic of hepatic fibrosis have been verified in many domestic and abroad in vivo and in vitro's studies of hepatic fibrosis. Moreover, CTGF can strongly regulate the proliferation of hepatic stellate cells, and its uncommon highly expression play an critical role in development of hepatic fibrosis, becoming the hotspot in hepatic fibrosis studies. But as for the researches about CTGF in hepatic fibrosis, abroads′focused on cell culture and clinical aspects,...
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