Anti-inflammatory Effect Of ABL In Experimental De-endothelium And Hyperlipidemia Rats

Objective: 1-o-acetylbritannilactone (ABL) extracted from Inula Britannica-F can inhibit NF-kB activity. To confirm the anti-inflammatory effect of ABL on the neointima formation, the present study tested the level of C-response factor (CRP) and prostaglandin E2 (PGE2) as well as neointimal thickness by balloon de-endothelialization after administration of ABL.Methods: 1 Establishment of animal modelsHyperlipidemia model: SD rats were randomly divided into three groups: normal group, high-fat group and high-fat with ABL group. Normal group was fed with general diet. High-fat group was fed with high-fat diet for 60 days. High-fat with ABL group was treated with ABL for 21 days after given high-fat diet for 40 days. ABL was given through intragastic administration by 26 mg per kilogram per day.De-endothelialization model: SD rats were randomly divided into three groups: normal group, model group, and model with ABL group. Model group received arterial de-endothelialization procedure. Model with ABL group was treated with ABL. ABL was given each day by 26 mg per kilogram until the end of experiment. The rats were killed after...