A Study On SARS Cases Prognosis For Two Years In T Lymphocyte Subgroup

Objective: To study changes of the SARS patients'T lymphocyte subgroupprognosis for two years, and to investigate these changes'influential factors and developing mechanism.Methods: To follow-up investigate 100 SARS cases for prognosis two years inMay, 2005 and to use 29 healthy blood donors as control. Then to collect theepidemiology baseline data and health examination data, at the same time, to draw off 5ml anticoagulation blood from ulnar vein, in which detect the ratio of peripheral blood CD³⁺,CD⁴⁺ and CD⁸⁺ T lymphocyte by employing flow c-ytometer and detect the peripheral blood leucocyte count and classificationby employing whole-automatic cytoanalyze.Results: 1. There are 70 patients on CD₄/CD₈<1.5, 30 patients on CD₄/CD₈>1.5 in the 100 final diagnose SARS cases; CD³⁺CD⁴⁺ in case groups(30.29±7.69) % is lower significantly than the controls (43.15±2.99) %, ( t=6.12, p<0.01); CD³⁺CD⁸⁺ T lymphocyte rates in cases (69.51) is higher si-gnificantly than the controls'(49.45),(z=-2.54,p<0.05); CD³⁺/CD⁸⁺ T lymphocyte rates in cases(56.43) is lower significantly than the controls(94.55),(z=-4.84,p<0.01); The lymphocyte's absolute value in cases(0.83±0.44) is lo-wer significantly than the controls (1.87±0.68),(t=9.71,p<0.01).2. There is not diference on CD₄/CD₈ value from gender,age,smoking and drinking or not (t=-1.90,-0.09,1.40,0.395 respectively, p>0.05).3. There is significant difference on CD₄/CD₈ value in case groups between employing immunomodulator and not employing immunomodulator (t=2.81, p<0.05), and the former's value is lower significantly than the later's; There is not difference between applying glucocorticoid and not applying (t=1.097, p<0.0 5); There is not correlativity among the total amount of hormone, daily mean amount, odd-numbered days maximal dose, time of using hormone and CD₄/CD₈ value (r=-0.21,0.162,0.073,-0.125 respectively, p>0.05).4. In the period of morbility, there is not correlativity among percentage nadir,a-bsolute value nadir,SaO2 nadir,PaO2 nadir,bellows extent of disease of lymphocyte an-d CD₄/CD₈ (r=0.129,0.05,0.165,0.179,0.001 respectively, p>0.05).5. There is not correlativity among CD₄/CD₈ value and pathological changes severity on bone syntaxis,occurrence of pulmonary fibrosis (r=-0.078,0.001 resp-ectively, p>0.05).Conclusions:1. The 70.00% CD₄/CD₈ value descend and even invert, and immune systemsuffers from severe impairment.2. The pathological lesion in immune system may to be present for long time as SARS COV infect; The immune system'impairment is the important pathogenesy of SARS.3. The using of immunomodulator aggravate to damage the immune function, but not the reason of immune function impairment. So, as treat SARS, it should be careful to use immunomodulator.4. The immune function impairment on SARS prognosis for two years may be the disease's developing course.