Application Of Biofluid ～1H NMR-based Metabonomic Techniques To Analyze Plasma Of Patients With Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is one of the sixth most frequently occurring cancers, oral cancer is the most common cancer affecting peoples' life and the incidence have been rising in recent years. Searching for an accurate and noninvasive screening test for precancerous became more and more exigent. Blood plasma is the major vehicle by which metabolites are transported around the human body, and chemical analysis of plasma can provide a wealth of information at the molecular level relating to the biochemical status of an individual and is important for diagnostic purposes. Further evaluation of plasma proteins associated with oral cancer holds promise for the development of a tumor marker panel that could be helpful in the early diagnosis of oral cancer.~1H nuclear magnetic resonance (NMR) based metabonomic and pattern recognition analysis (PRA) is increasingly being used to monitor metabolic abnormalities within cells and intact tissues in order to detect the cancer sensitively and rapidly. Metabonomic analysis of human biofluids is rapidly developing in clinical research .The application of high-throughput genomic...