The Research On Growth Hormone Receptor Expression In Normal Esophagus As Well As Esophageal And Cardial Cancer

Objective: To investigate the expression of growth hormone receptor in normal esophagus as well as esophageal and cardial cancer, and evaluate the role of growth hormone in normal esophagus and in the development and progression of human esophageal and cardial cancer.Methods: The expression of GHR were detected by immunohistochemistry technique in cancer specimens and paired normal esophageal tissue from 50 patients with esophageal or cardial cancer.Results: 41 case of esophageal cancer and 9 case of cardial cancer were enrolled in this research. GHR expression was detected in all normal esophagus and 82% of cancer tissue. The expression of GHR was higher in the normal esophagus compared to the cancer tisuue(p<0.001). The expression of GHR was significantly associated with tumor differenciation(p=0.034), and pathological staging(p=0.023). No relationship between the expression of GHR and preoperational nutritional status was found.Conclusions: The administration of growth hormone in perioperational...