| Objectives: The primary aim was to assess the efficacy of local advanced renal cell carcinoma with or without postoperative interferon-alpha adjuvant therapy, including the incidence of overall survival rate, Recurrence free rate. The secondary objective was to compare treatment-induced adverse effects.Methods: According to the Cochrane reviewer's handbook, included studies were those on patients with histologically confirmed local advanced renal cell carcinoma. The search strategy was developed according to the Collaborative Review Group search strategy. Medline, Embase, CBM, Cochrane library, articles in the academic degree collections were searched for clinic trails comparing efficacy of local advanced renal cell carcinoma with or without postoperative interferon-alpha adjuvant therapy. In addition, the reference articles of each selected trial were hand-searched. Trials of RCT would be assessed for quality according to the concealment of...
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