The Effect Of Dynamic Mechanical Strain In The Osteoblastic Differentiation Of Mice Adipose Derived Stromal Cells: An In Vitro Study

Cell-based therapies that exploit the regenerative potential of adult mesenchymal stromal cells (MSCs) will be a substantial improvement over current treatment of skeletal defects and deficiencies, including the alveolar bone defect. MSCs are a heterogeneous population of cells defined by an ability to differentiate to various mesodermal lineages. Several types of adult MSCs have been investigated; in particular, adipose-derived stromal cells (ADSCs) have generated great interest by their multi-lineage differentiation capacity in vitro and their relatively abundant and easily accessible source.Mechanical stress is the one of the fundamental biological stimulations in the evolution as well as one of the fundamental physiological factors for regulating structures and functions in bone. It has been proved that the mechanical stress can stimulates osteoblastic differentiation of bone marrow stromal cells (BMSCs). Therefore, as an alternate source of adult stem cells, ADSCs should be fully realized of their response to the mechanical stress in their osteoblastic differentiation before they are applied in the engineered bone.