The Preparation And Related Research Of Calcium Sulfate Combined With Bone Matrix Gelatin As Bone Graft Substitute

BackgroundsIt is always an important subject to search ideal bone graft substitute for repairing bone defects in orthopaedics. Autograft is generally considered to be the gold standard in bone graft surgery because of its great osteogenic capaciey. But, its limited quantity and the surgical complications of the harvest site are common the disadvantages. In addition, autografts cannot be fabricated into customized forms. These limitations have prompted increasing interest in alternative bone grafts. Such alternatives range from the simple, such as calcium sulfate and calcium phosphate materials, to the complex that contains allograft extracts, bone morphogenetic proteins, or other bone growth agents. The use of calcium sulfate as a synthetic bone graft substitute was documented as early as 1892 by Dreesman. Lots of studies demonstrated that calcium sulfate can be resorbed and is well tolerated by tissues. As an osteoconductive material, calcium sulfate allows ingrowth of blood vessels and osteogenic cells. Many animal and clinical tests have been conducted to evaluate allograft as an osteoinductive material, and bone matrix gelatin(BMG) has been found...