The Influences Of MP On The Changes Of MBP In Acute Spinal Cord Injuried Rabbits And Related Clinical Research

1. ObjectivesFor the past ten years patients with acute spinal cord injury (SCI) increased gradually because of the development of freeway and high buildings. The treatment after SCI was tightly related with the living quality of future. Now there were lots of basic and clinical researches in the molecule mechanism. But the definite treatment mechanism of Methylprednisolone, the only drug confessed by the whole medical world , is still in hand. Myelin basic protein (MBP) is the main protein composed of the central neuron system (CNS), which maintains the stabilization of structure and function of CNS. Some researches have revealed the increase of serum MBP concentration in the patients suffered from trauma or acute disease of CNS, while the blood-spinal or blood-brain barrier was destructed. There is few researches focus on the relation of MP and MBP in the scenario of SCI. MP also is gradually applied in the perioperation of SCI and chronicle myelopathy, especial in the cervical spondylosis. But the clinical trial on the specific usage and related complication of MP is scarce.This study aimed to evaluate the relation between MP and MBP by the experimental animal SCI model, and the clinical effects of MP, including:1. To establish SCI animal model and observe difference of the MP group and contrast group by monitoring the serum MBP concentration by ELISA. To investigate the neurological regeneration function of MP by pathology and electrophysiology.2. To evaluate the neurological regeneration function and complication of MP by the clinical perspective contrast study.