Immunohistochemistry And Morphology Research Of Rat Mammary Stem Cells

Mammal's mammary gland is a compound tubuloacinar gland. Because multiplication and differentiation passes through the mammary gland growth, People have carried on the massive multiplication and differentiation research about mammary gland epithelial cells in the cell level. The research discovered the mammary gland cells death in the differentiation process. In order to compensate this insufficiency, Mammary gland retain a part of undefferentiated cells in growth evolution process, which is called mammary stem cells. These stem cells may according to the certain way to produce the differentiated cells. As early as in 1959, De Ome confirmed: mammary epithelial cells could regenerate the mammary gland. The further transplant research also indicated that the mammary epithelial cells had the self-duplication ability, which might maintain to the 7th transplant. In 1999, Chepko and Smith confirmed: there was a mammary gland cell line (lineage) in the mammary gland. As a result of particularity growth of mammary gland, the relations between dysdifferentiation and breast tumor, Mammary gland was an extremely appropriate model to study the organogeny, the cell differentiation and the organ reparative regeneration.At present, the research of mammary stem cells was still in the start stage. Many questions needed to solve, such as the specificity marks. If there had no idea to...