Effects Of Magnesium Sulfate On Early Injury-repair Of Coronary Artery After Percutaneous Transluminal Coronary Stent Implantation

Objective The present study was conducted to explore the effect of magnesium sulfate on early injury-repair of coronary artery after percutaneous transluminal coronary stent implantation by observing endothelial dysfunction,platelet and blood congulation activation,inflammatory reaction and intimal proliferation and apoptosis and to provide evidence and reference in clinic for diagnose,prevent and treat restenosis after percutaneous coronary intervesion.Methods Patients with at least 50% percent coronary stenosis proved by coronary arteriography were involved and randomly divided into three groups, as magnesium group(15 patients), percutaneous coronary intervesion(PCI) control group(15 patients) and coronary angiography(CAG) control group(21 patients). Percutaneous transluminal coronary stent implantation was performed in both magnesium group and PCI control group, while coronary arteriography was conducted in CAG control group. In magnesium group, 5g magnesium sulfate were intravenously infused per day from 3 days before operation to 3 days after operation. Serum ET-1,TXB2,6-Keto-PGF1α,P-selectin of platelets,Fbg,CD11b of leukocyte,hs-CRP,AngII,Fas ligand of leukocytes were tested at 3 days and 1 day before operation and half an hour, 1 day and 3 days after operation. The change tendency of variables was observed and their difference between each groups was analyzed.Results There was significant difference in all of the variables in both magnesium group and PCI control group, but no significant difference in CAG control group. The level of ET-1,TXB2,6-Keto-PGF1αat half an hour after operation in both magnesium group and PCI control group were significant difference compared to those of the control group and those before operation (P<0.01). There was also significant difference between magnesium group and PCI control group at half an hour and 1 day after operation (P<0.01). The change of P-selectin of platelets was similar at half an hour after operation, Fbg at 1 day after operation. The level of CD11b of leukocyte,...