| Objective: To study the effect of Iiposomal Prostaglandin E1(Lipo-PGE1) on kidney function during cardiopulmonary bypass(CPB) in cardiac valve replacement.Methods: 20 patients scheduled for cardiac valve replacement undergoing CPB were randomized into two groups: group L (n=10) and group C(n=10). patients in group L were administered 3ng/(kg· min) of Lipo-PGE1 and some other Lipo-PGE1(5ng/ml) was added to the priming solution of the extracorporeal machine. patients in group C were only administered the same volume of normal saline in the same way. a1-microglpbulin(a1-MG), β2- microglpbulin (β2-MG), Thromboxane B2(TXB2) and 6-keto-Prostaglandin F1a(6-keto-PGF1a) were measured at pre-CPB(T1), 30 min of CPB(T2), the end of CPB(T3), 1H after CPB(T4) and 24H after CPB(T5). At the same time, the TXB2/6-keto-PGF1a was calculated. The creatinine and urea nitrogen of pre-operation in blood, the frusemide used and the volume of liquid into patients' body in operation, and the volume of urine in operation and 24H after operation were observed.Result: (1) There were no signification differences between the two groups in ecumenical things. (2) a1-MG and β2-MG: a1-MG and β2-MG was higher than baseline at T2～T4 in both group. The highest were at T3 (P<0.01). At same time a1-MG and β2-MG in group L were lower than in group C(P<0.01). (3) TXB2, 6-keto-PGF1a and TXB2/6-keto-PGF1a: TXB2, 6-keto-PGF1a were significantly higher than the baseline at T2～T4, the highest was at T3(P<0.01). TXB2 at same time in group L was lower than in group C (P<0.05). 6-keto-PGF1a at same time in group L was higher than in group C (P<0.01). TXB2/6-keto-PGF1a was higher than the baseline from T2, and the highest was at T3. In group L it decline to the baseline at T4 and this phenomena can be seen at T5 in group C. And TXB2/6-keto-PGF1a was lower in group...
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