Relationship Between Serum Adiponectin Level And HCV-related Chronic Liver Disease In Patients.

Aim: To study the relationship between serum adiponectin level and HCV-related chronic liver disease in patients.Methods: Total seventy patients were randomized into two subgroups as follows: 1) control group (n = 20); 2) HCV-related chronic liver disease group (hepatitis: n = 20: liver cirrhosis: n = 20; primary hepatic carcinoma, n = 10). Serum adiponectin was determined by the ABC-ELISA method. Biochemical parameters (AST, ALT, GGT, TBIL, DBIL) were also examined. Pearson correlation analysis was applied to study the relationship between serum adiponectin level and the severity of liver injury. Results: Compared to the control and hepatitis groups, HCV-induced liver cirrhosis and primary hepatic carcinoma showed an increase in the serum levels of adiponectin (liver cirrhosis: 10.94 ± 2.33 mg/L; primary hepatic carcinoma: 12.10 ± 2.24 mg/L, P < 0.01 vs. control and hepatitis groups). Pearson correlation analysis revealed that serum adiponectin levels positively correlated with serum levels of AST. ALT. GGT. TBIL, and DBIL (P < 0.01). In the control group, the serum adiponectin levels were higher in female than that in male but not in patients with HCV-related chronic liver disease. Conclusion: Serum adiponectin level is increased in HCV-related chronic liver...