The Expression Of NF-κB And Bcl-2 Gene In Human Extrahepatic Cholangiocarcinoma And Their Significance

The expression of NF-κB and Bcl-2 gene in human extrahepatic cholangiocarcinoma and their significanceDepartment of General Surgery,Jiangsu Province Hospital,NanjingMedical University,Nanjing 210029,ChinaObjectiveTo study NF-κB expression in extrahepatic cholangiocarcinoma tissues and its correlation with the pathological stage of cancer tissues and the expression of Bcl-2. MethodsBy means of immunohistochemical SABC method,the expression of NF-κB and Bcl-2 were compared between the extrahepatic cholangiocarcinoma tissues from 48 cases and normal bile duct tissues from 12 cases. ResultsThe positive expression of NF-κB in the extrahepatic cholangiocarcinoma group and the control group were 75%, 16.7% respectively (p<0.01).The positive expression of Bcl-2 were 64.6%,8.3% respectively (p<0.01).The positive of NF-κB was significantly different for different pathological grades(p<0.01) and the expression of Bcl-2 was...