The Expression And Significance Of Syndecan-1,MMP-1 In Breast Carcinoma

Breast carcinoma is amalignant disease which Seriously threates female health, The incidence of breast carcinoma a ccounts for the first position of female malignant tumors. Researching deeply the mechanism of the carcinogenesis and development of breast carcinoma have important significance for the choice and implement of the treatment and prevention measures of breast carcinoma.Inrecent years,the studies about the function of adhesion molecules have gradually increased and validated their important significance in the carcinogenesisand development of the tumors. Syndecan-1, an important member of Syndecan family,is a transmembrane heparan sulfate proteoglycans cell adhesion molecule. Syndecan-1 binds a series of extracellular ligands via its covalently attached heparan sulfate chains, mediates cell-matrix,cell-cell adhesion,maintains the completion and stability of normal epithelia morphology and structure;takes part in the carcinogenesis and development of the tumors by modulating cell proliferation,influencing cell migration. Disruption of basement membrane integrity,a feature of invasive tumors, allows tumors to spread locally and distantly.It was believed that the MMPs, via breakdown of the physical barrier, were primarily involved in tumor invasion, blood vessel penetration and metastasis. Among the MMPs,MMP-l is the most highly expressed interstitial colagenase degrading fibrillar collagens, and the most abundant protein in the human body. The overexpression of MMP-1 has been demonstrated in tissue of tumors and has been suggested to be associated with tumor invasion and metastasis.At present,the documents reporting the relations of Syndecan-1 expression and the...