| Background and ObjectiveTraumatic brain injury (TBI) is of frequent occurrence, which is the main cause leading the patient to injury or death. Diffuse brain injury (DBI) is the most common TBI. Epidemiological investigation shows DBI comprises 73% of the total serious brain injuries in road accidents. For a long time, DBI is considered the main cause of continued coma and serious nerve hindrance. Statistics show 55% of seriously brain injured patients suffered from DBI. After DBI, a seris of pathological and physiological changes tend to happen, metabolic disorder of various substances in brain tissue would occur. The study in this regard is now going deeper and deeper, but the root cause is not clear yet ,which impedes the progress of therapeutics. A further study of the root cause and pathological and physiological changes after injury so as to find out effective means of brain protecting treatment will help increase the rate of survival and quality of life. We have modified DBI model of Marmarou. By use of this model, we have observed pathological and physiological changes of the brain tissue after injury and tested expressive changes of glial fibrillary acidic protein (GFAP) in the responsive Astrocyte. In addition, we have also made a careful study of the rules of change of nitric oxide (NO) and endothlin (ET) in brain tissues of brain injuried rats at different times and their interrelations in an attempt to get to know the pathological root cause of brain injury, thus laying a solid foundation for further...
|
PDF Full Text Request