Expression Of Midkine, CD105 And VEGF In Colorectal Carcinoma And Its Clinical Significance

Midkine(MK) is a new heparin-binding growth factor. During embryogenesis, MK is highly expressed in the mid-gestational period, but it is only expressed in some special tissues after birth. What's more, MK can affect the biological activities of carcinoma cell including subsistence, proliferation and differentiation. CD105, also named endoglin, is the one of the component of the transforming growth factor receptors. It expresses only on tiny blood vessel endothelium cell of the active proliferation carcinoma. VEGF is the most critical vascular endothelial growth factor . We used immunohistochemical technique to evaluate the role of MK protein in tumorigenesis of colorectal adenocarcinoma. Also we investigated the relationship between the expression of midkine(MK), CD105 and VEGF in colorectal carcinoma and the biological behavior and prognosis of colorectal carcinoma.Material and Methods: The expressions of MK, VEGF an CD105 in 50 cases with colorectal adenocarcinoma tissues, 18 cases of colorectal adenomas and 17 cases of normal colorectal tissues were examined by using S-P immunohistochemistry . SPSS11.0 was used to evaluate the statistical significance.Results: (1) in normal colorectal tissues, colorectal adenomas and colorectal adenocarcinoma, the positive rates of MK were 5.9%(1/17), 55.6%(10/18), 72.0%(36/50). There were significant differences (P<0.01) when colorectal adenomas and colorectal adenocarcinoma compared with normal colorectal tissues. (2) the...