Study On The Growth Inhibitory Effects Of OGP46 In EC9706 Cells Both In Vivo And In Vitro And Its Mechanisms

BackgroundCancer is the second leading cause of death in the world, and esophageal cancer (EC) is the sixth leading cause of cancer death. On a global basis, the incidence and mortality of EC in Chinese both are the highest. Thus, there is an urgent need to find effective drugs and methods in the prevention and therapy of EC, in order to decrease the incidence rate and increase the survival rate. With the rapid development of molecular biology and molecular oncology, the molecular mechanism of carcinogenesis of esophagus is clarifyed continuously. At the same time, it provides many new targets for anticancer treatment. Among these targets, the apoptosis genes and proteins in apoptosis pathways are very important, inducing apoptosis through them is focused on in most research. Telomerase also became a novel target for EC diagnosis and therapy, because itplays a very important role in cell immortalization and tumorigenesis.Rabdosia rubescens has got extensive attention of the scholars all around the world as an anticancer herb that has strong anticancer activity and weak toxicity. While up to now, no new anticancer drug has been developed from it. Using the active components of Rabdosia rubescens as lead compounds, OGP46 was designed, synthesized and screened out in the New Drug Research and Develop Center of Zhengzhou University. OGP46 is the first anticancer objective compound extracted and screened out from Rabdosia...