| [Background]Though a lot of reasons may be involved in the failure of gastric cancer chemotherapy, multidrug resistance (MDR) plays the key role in it. The aim of reversing MDR of gastric cancer cells is to entirely or partly recovery their chemotherapy to drugs, which has become a hot spot in solid tumor MDR research nowadays. Reversing drugs, like quinidine, anti-estrogen, are restricted to clinical application because of their poor efficiency and poisonous side-effects. So it will be a breakthrough to find out some new effective ones. Previous studies indicated that some specific but unknown membrane molecules which were closed related to MDR and absent in chemosensitive cell lines existed in MDR cell lines, which may provide a new angle for us to find out those specific ones and elucidate the underlying mechanism of gastric cancer MDR. Thinking about the varieties of such molecules, it is impossible to detect purity or block them one by one. However, the development of phage peptide library panning technique as an efficient selection system provides us a good way to obtain the specific ligands binding to the target molecules. Here we have screened the peptides binding to gastric MDR cells... |
