Screening For Multidrug-resistance Gastric Cancer Cell Specific Binding And MDR Reversal Peptides Using Phage Display Peptide Library

[Background]Chemotherapy is one of the main treatments of cancer. However, despite of the emergence of new reagents and schemes of chemotherapy, the clinical outcomes of chemotherapy have not been improved significantly. The main reason is that the cancer cells have developed multidrug resistance (MDR) to chemotherapy drugs. Thus, it has great significance to clarify the cause of MDR and explore the effective ways to reverse MDR. However, most MDR reversals don't work efficiently and have too much side effect. Therefore it becomes hot in this field to find novel MDR reversals.[Objectives]To identify the peptides which bind specifically to MDR gastric cancer cells and could reverse MDR phenotype using phage display peptides library.