The Protective Effects Of Adenosine On Ischemia/reperfusion Injury Of The Donor Lung During Combined Heart-lung Transplantation In Canine

BackgroundCombined heart-lung transplantation has evolved from an experimental procedure to an accepted therapeutical option for patients with endstage cardiopulmonary failure. But optimizing posttransplantation graft function is still a continuing challenge in combined heart-lung transplantation. Ischemia-reperfusion injury and the resulting primary graft dysfunction remains a persistent cause of early graft loss in combined heart-lung transplantation , the dysfunction of donor lung caused by ischemia-reperfusion injury is the important reason to the failure of combined heart-lung transplantation . The manifestations of lung ischemia-reperfusion injury can be characterized by increased pulmonary vascular...