Neuroprotective Effects Of Recombinant Human Erythropoietin In The Neonatal Rats With HIBD

BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is the severe complication of neonatal asphyxia, which is a main statement with high mortality. It often causes neonatal death and stunted in nervous system. So to understand the pathogenesis and to seek effective treatment is the one of the major objectives in neonatal researches. Erythropoietin, (EPO) is important hematopoiesis which binds to a surface receptor (EPO-R)on erythroid progenitor cells. Recently, EPO has emerged as a multifunctional growth factor that plays a significant role in the nervous system. Both EPO and its receptor are expressed throughout the brain in glial cell, neurons and endothelial cells. Based on these studies, it has been major to many researchers. Recombinant human erythropoietin (rhEPO) has been made use in the clinic about 20 years, but protective mechanism of rhEPO after HIBD in neonatal is still uncertain. Our studies the expression of NR1 positive cells with immunohistochemistry, neurons apoptosis with terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling (TUNEL) staining and NO activity,...