| Objective: Carcinogenesis is related to cellular proliferation, differentiation and apoptosis closely. Survivin, a member of the inhibitor of apoptosis protein family, is a newly identified bifunctional protein that suppresses apoptosis and regulates cell division by affecting the final stage of apoptotic pathway. COX-2 is an important protein related to carcinogenesis by promoting cell proliferation, angiogenesis and inhibiting apoptosis. In our study, we want to detect the expressions of survivin and COX-2 in gastric cancinoma and the correlation of their expressions to clinicopathological parameters, so as to explore the roles of Survivin and COX-2 in gastric carcinogenesis.Methods: 51 cases of gastric carcinomas and 47 cases of peri-carcinoma tissues were obtained by gastroscope biopsy. Immunohistochemistry was used to detecte the expressions of Survivin and COX-2 protein.. SPSS 11.0 was used to analyze the correlation of the protein expressions to clinicopathological parameters.Results: 1 , The expressions of Survivin and COX-2 in gastric carcinoma cases and peri-carcinoma tissues :The positive rate of Survivin and COX-2 in gastric carcinoma ( 70.58%, 68.63 % ) were significantly higher than that in peri-carcinoma tissues (36.17%, 30.04%) ( P < 0.05 all);2, The correlation of Survivin expression to the clinicopathological parameters in gastric carcinoma:The positive rates of Survivin in the groups with serosal invasion , lymph node metastases and TNM stage â…¢-â…£ (78.04%,94.59% and 88.57% .respectively), were siginifcantly... |
