Experimental Study Of Wuzhuyu Decoction On Pharmacodynamics And Effective Mechanism In Peptic Ulcer

Objective:The topic aims to provide the objective evidences of Wuzhuyu decoction in anti-ulcer based on the pharmacodynamics. And to explore the impossible effective mechanism from two aspects of attacting factor and protecting factor to provide experimental evidences for clinical application. Method and Result :To make the rat models of peptic ulcer(PU) by water-immersion stress, by painting the surface of stomach with acetic acid and by ligating the pylorus is to discuss the function mechanism of WZYD resisting ulcer on the basic of pharmic.The results indicate that WZYD has the obvious treatment and prevention effects on acute and chronic PU model making by all kinds of ways. It is one of the function mechanism of increasing the level of 6-K-PGFia, the stoamch tissue SOD activity and contents of NO in gastric juice and controling active pepsin and decreasing the level of total acidity of gastric juice. It indicates that WZYD can exert the anti-ulcer effect through controling attacting factor and promoting protecting factor. And it validates the scientifical and reasonable value of the method of warming middle and reinforcing deficiency , descending the adverse rising-qi and dissipating cold in anti-ulcer. This study provides referenced evidence in resisting ulcer medicine in clinic and exploring new medicine .