The Mechanisms And Effect Of Adenosine A_2B Receptor Antagonist In Mouse Asthmatic Model

Objective: Asthma is a respiratory disease with a high incidence in children, which is characterized by chronic lung inflammation and airways hyperresponsiveness. It always obstructs the health and growth of children because of repeated attacks. The mechanism of asthma is very complicated. More recently, the level of adenosine has been shown to be increased its attack in asthmatics, and which played an important role in bronchoconstriction of asthmatic patients. It has been proved that inhaling adenosine could provoke bronchoconstriction in asthmatics. There appears adenosine interacts with A2B on mast cell to potentiate secretion of IL-8 and produce bronch- inflammation. So, presume A2B receptor as a therapeutic target, if A2B receptor is blocked selectively, which provide a better protection against mediator release and bronchospasm. The goal of this study is to observe the possible role of A_2B receptor antagonist, Xanthine amine congener (XAC), played in preventing ovalbumin-induced mouse asthmatic model, through optical density and gray of positive area of immunohistochemistry staining, thickness of bronchus wall and smooth muscle, measured by computer image analysis system, and the level of IL-8 in blood-serum. The appreciation of the...