Studies On Pharmacokinetics Of Nepofam Hydrochloride During Epidural Anesthesia

Nepofam Hydrochloride is central analgesic without anaesthesia.It's painful function is equal to morphine ,it's addiction and side effect are all small.It also has the advantage of reliving pain.loosing muscle.reducing the heat.and the anti- melancholy function.It has no anaesthesia .no quiet function and does't repress central nervous system.It can loose muscle and can agree with stomach .does't stimulate and cause issue of blood,it can reunite an application with various medicine.Compare to opium,it has no dependence and tolerance,has no function towards breathing and circulatory system.Now,in clinical,the method of relieving surgical pain is launched extensively,Nepofam Hydrochloride was injected in epidural pump.But the study at home or abroad,only report the orally and intravenous injection pharmacokinetics .Inquiry into the pharmacokinetics of nepofam contribute to our first step to comprehensively understand this medicine in body process and the rationality after neurocanal anesthesia.On the base of characteristic ultraviolet absorption of nepofam hydrochloride ,the high performance liquid chromatography(HPLC) methods was established for analysis of nepofam.The linearity.specificity.repeatability and recovery met with the requirements of Chinese pharmacopoeia(edition 2000).In the bioavailbility experiment, the nepofam concentration was analyzed by HPLC injected through eqidural anesthesia.Parameters were estimated by Winnolin pharmacodinetics software. The results showed that: The Nepofam Hydrochloride can be absorbed in plasma when it was acceped epidural anesthesia and the plasma concentration-time curves of Nepofam Hydrochliride was fitted to a one-compartment open modle.It's dispersibility is so big that it can relieve pain fastly during epidural anesthesia.A HPLC is a stable,simple and sensitive method for determination of plasma Nefopam concentration during epidural anesthesia . the main pharmacokinetic parameters are Tpeak(1.3±0.13)h, t1/2(5.23±1.94)h, Cmax (253.86±14.43) ng/ml.