The Clinical Observation And Correlative Study Of Kidney Origin Decoction Treating Chronic Renal Failure

Character renal failure is the clinical synthetical symptommade of a series of symptom or metabolize turbulence, is theprocessive renal functional damage made by all the primary orsecondary diseases. There is no certain notable therapy with westmedicine to prevent or postpone the processive renal functionaldamage of CRF sufferer to improve living quality, prolong life.Character renal failure , in TCM, belongs to dropsy, barrier,emptiness syndrome, close or pour disease waist pain, and, ect.The pathogenic mechanism is not false but also true, not negativebut also positive aspect. Commonly regarded, weak vital energyand true pathological product go throw this disease from the beginto the end. Weak vital energy include the negative, and positiveaspect, gas and blood, the internal organs, true pathologicalproduct include outer evil, liquid and damp, damp and heat, bloodstasis, phlegm. This research set up contraposing the CRF clinicaleffect, based on the wholism conception and treatmentdetermination based on syndrome differentiation in TCM, theprinciple is increasing healthy and liquid, enrich kidney, at thesame time, eliminating damp and blood stasis, The research sets upthe systemic clinical observation and study in character renalfailure using purifying kidney decoction, and aims at the clinicaleffect and approach the mechanism of this decoction.There are 84 cases in this research, all from TCM departmentand renal medical department of China-Japan Union hospital ofJilin University, the male are 42 cases, and the females are 42, theage of them is from 18—65, the average age is 41.5, divided intotherapy group and control group in random, and there is 48 cases intherapy group, 36 in control one. All of the cases are diagnosed ascharacter renal failure according to the , and , and bringinto case history according to ,, and all the patients haven'thad correlative drugs in last 2 weeks. Base treat:①LPD:excellentlow albumen, proteid 0.6g/kg · 24h, low phosphor sup, andguarantee thermic(30 ～ 40kcal/kg · 24h ). ② control bloodpressure:control from 17.3-18.7/10.7-12.0kPa, general medicationis autunite resisted medicine, adjusting the dosage basing on bloodpressure at any moment.③diuresis:deciding weather to use diureticand dosage basing on stale quantity, generally, keeping at about1500ml/24h.④correct water, electrolyte turbulence, acid and alkalibalance maladjustment. ⑤ notice to eliminate inducement, useantibiotics to cure infection.⑥no using some medicine of droppingfat, correcting anaemia and regulatoring immunity.⑦no using themedicine of damaging kidney and infecting this test.Therapy group: purifying kidney decoction , 100ml, b.i.d oral.Basic prescription: Astragalus Membranaceus, Field Thistle, RubiaRoot, Japanese Thistle, Rehmania Root, Honeysuckle Flower,Forsythia Fruit. If there are symptoms of outside disease, get rid ofAstragalus Membranaceus,add with other medicine , such as Vites;the heavy turgescence is added with Rubia Root ,Tuckahoe,luster;the naupathia and spew is added with Ageratum;urinealbumen is distinc with Astragalus Membranaceus;hematuria is inevidence with Thistle;the positive is weak with spleen andkidney,added Acontum carmichaeli Root;hematuric acid is highwith Luffa cylindrical.( all Chinese herbs are decocted in TCMpharmacy of China-Japan Union hospital ). Control group: routinetherapy with west medicine. Therapy course: 4 weeks as a onecourse, 2—4 courses consecutively.The result: ①The patients' urinalysis SCR, BUN decreaseddistinctly in therapy group after taking purifying kidney decoction,dealt with statistics( P<0.01 ), has the difference significance. ②The UA declined in therapy group after taking the decoction,dealt with statistics( P<0.01 ), has the difference significance. ③The decoction can increase HDLC in therapy group, dealt withstatistics( P<0.01, P<0.05 ), has the difference significance. ④The can also decrease 24Upro, dealt with statistics( P<0.01 ), hasthe difference significance.There are conceivable common usage for current medicinecan help pathogeny and progress of CRF in such following aspects:kidney globulecirrhosis, kidney tubule damnification and fibrosis,grease metabolize turbulence, gene excessive form andalbuminuria, uraemia toxin, the above bring with damage to thekidney. The Chinese medicine believe The pathogenicmechanism is not false but also true, not negative but also positiveaspect. Commonly regarded, weak vital energy and truepathological product go throw this disease from the begin to theend. Weak vital energy include the negative, and positive aspect,gas and blood, the internal organs, true pathological productinclude outer evil, liquid and damp, damp and heat, blood stasis,phlegm. So adopt benefit kidney , discharge turbid and gore, inorder to support with the positive and not to like evil, dispel eviland not to injury the positive. This is the theory foundation ofpurifying kidney decoction. Basic prescription: AstragalusMembranaceus, Field Thistle, Rubia Root, Japanese Thistle,Rehmania Root, Honeysuckle Flower, Forsythia Fruit. Increasingenergy and nourishing kidney work together. It will bring muchefficacy;ZeXie and DaHuang are subject medicine they can wetileus;DanShen and NiuXi are adjuvant, they can dredge bloodblock. The whole prescription is able to improve tiny circulation,resist fibrosis, adjust grease metabolize, drop urine albumen,urinetoxin and resis inflammation, improve and hold CRF patients'state of an illness. Astragalus Membranaceus can increase energy,do detumescence. And improve Na ion metabolism. Adjusting fatmetabolism and improving serious coagulation is its own importantfunction too;ShouWu can nourish kidnap, energy and blood, andkeep the thymus young,.otherwise, it can decrease cholesterin, andreduce the fat aggradation. The combine of these two medicine willbe able to keep body cleanliness and wipe off poison to improvekidnap status. Rubia Root and Japanese Thistle both can reduceaggradation, improve nitrogen and anhydride increasement,drainage of Na, Ka and Cl. At the same time , decreasecholesterin and resist artery cirrhosis.Honeysuckle Flower andForsythia Fruit both can make medicine go down and resist bloodcurdling;have other functions , for example, distend blood vessel,amend tiny circulation, drop fat, resist fibrosis, keep and amendkidney function. Besides, some studies indicate they have thefunction, such as adjust kidney cell immunity .Generally speaking, the method of benefit kidney,releaseturbid and gore, in treating Character renal failure, has broughtmore and more attention. At the same time, it is found that theChinese decoction can modulate immunoglobin. After in-depthstudy, the therapy with Chinese decoction, based on syndromedifferentiation, will play more and more important role .