Comparison Of The Changes Of Extensor Digitorum Longus In Hibernating Ground Squirrel (Citellus Dauricus) And Hindlimb Disuse Rat

Background: More and more researchers in clinical and space medicine have being focused on skeletal muscle disuse atrophy. The clinical and experimental research have proved that skeletal muscles of human being and rat, which were disused for some time, all would present disuse atrophy in a certain extent. But the skeletal muscles of ground squirrel (Citellus dauricus), a species of hibernating rodent, would not present any signs of atrophy as the individuals aroused from hibernation, even though the skeletal muscles undoubtedly were disused for several months in hibernation. Therefore to compare the different changes of skeletal muscles in hindlimb disuse rat and hibernating ground squirrel, maybe provide a way to find out the mechanism of anti-disuse atrophy of hibernating ground squirrel. Furthermore this research maybe help to the therapy and prevention of disuse atrophy in human being.We have studied the changes of slow twitch skeletal muscle, and had no any research on fast twitch skeletal muscle in hindlimb disuse rat. In addition, until now there were many different opinions on the changes of fast twitch skeletal muscle in disuse condition. Therefore we pay attention to the changes of EDL (one of fast twitch skeletal muscles) in this research.Objective: This research attempts to compare the different changes of EDL in...