Study On Variations Of Red-cell Immune Function And T-lymphocyte Subsets And On Relativity Between These Parameters In Henoch-Schonlein Purpura

Objective To observe the variations of red-cell immune function and T-lymphocyte subsets in patients with Henoch-Schonlein purura, to explore their roles and relationship in pathogenesis of Henoch-Schonlein purura.Methods 22 acute patients selected with Henoch-Schonlein purpura had been phlebotomized. Rose rate of red cells adhering to cancer cells(i.e. the innate immune activity of CR1 on erythrocytes) were counted according to erythrocyte quick innate immune reaction on cancer cells. At the same time, quantitative expressions of CR1 on erythrocytes and CD3~+, CD4~+, CD8~+T cells were measured respectively by Flow Cytometer through marking the samples. Healthy 18 cases as control groups.Results Compared with the healthy controls, rose rate of red cells adhering to cancer cells, expressions of CR1 on erythrocytes, CD4~+, and CD4~+/CD8~+ ratio were lower in patients with Henoch-Schonlein purpura(P<0.05), and CD8~+ were higher(P<0.05), and no change was found in the number of CD3+T lymphocytes (P>0.05) . There was positive correlation between rose rate of red cells adhering to cancer cells and expressions of CR1 on erythrocytes in healthy control groups (r=0.58,P<0.05) , while they didn't show the relationship in patients with Henoch-Schonlein purpura (r=0.36,P>0.05) . Furthermore, there was positive correlation between CD4~+/CD8~+ ratio and quantitative expressions of CR1 on erythrocytes in patients (r=0.67,P<0.01) .Conclusion In patients with Henoch-Schonlein purpura, erythrocyte innate immune function was found to be low and turbulent. At the same time T-lymphocyte subset ratio was maladjusted , and T-cell immune function was abnormal and disturbed. There was positive relativity between them. Red-cell native immune function and T-cell immune function possibly together take partin disease pathogenesis in patients with Henoch-Schonlein purpura. Furthermore, they effect and restrict each other.Postgraduate: Wu Na(DermatoloIogy) Directed by: Xiao Jun-gang(Professor)...