Clinic Analysis Of The 12 Cases Of Secondary Hemophagocytic Syndrome

Objective Probe into the cause of secondary hemophagocytic syndrome and its clinical and pathological characteristics. Methods Systematically review 12 cases of thesecondary hemophagocytic syndrome clinical record and analyze their traits and relations with prognosis. Analyze 3 of the 12 cases to find out the similarities and differences between autoimmune disease associated hemophagocytic syndrome and un-autoimmune disease associated hemophagocytic syndrome. Results In the 12 cases of secondary hemophagocytic syndrome , there was apparent peripheral blood cytopenia, liver dysfunction, height increase of reticulum cell of bone marrow smear, hemophagocytosis, a drop of neutrophilic alkaline phosphatase of bone marrow. All the three autoimmune disease associated hemophagocytic syndrome were medicine induced. The liver dysfunction precede peripheral blood cytopenia. In the two cases of adult onset still' s disease with hemophagocytic syndrome, the tendency chart displayed a classic concave shaped development. Conclusion Secondary hemophagocytic syndrome' s development involves consistent critical conditions, during which the immunodepression mechanism of the patient plays the major role. In the stage of secondary hemophagocytic syndrome, autoimmune disease associated hemophagocytic syndrome displays immunodepression.