Significance Of Combined Determination Of Serum Tumor Marker Around Chemotherapy

Research Background and objective:The primary bronchogenic carcinoma (abbreviated as lung cancer ) is one ofthe most common malignant tumor in our times, can find the difficult ,malignant intensity is high , the course of disease develops quickly in early days,become the main causes of death of human cancer ownly , is threatening humanlife and health seriously. Morbidity and mortality of lung cancer of countries allover the world have the tendency to obviously increase in the last half a century,the information that WHO was announced revealed in 1998: Lung cancer hasalready taken the global cancer morbidity and primary importance of themortality , 1,100,000 people died of lung cancer in the whole world in 1997. Soimprove and think to the competence of making a diagnosis and givingtreatment of lung cancer that there are very important meanings. Tumor mark ofserology ( tumor marker, TM ) is one of the important subjects that modernoncology is studied, serology TM of lung cancer measures have already becomethe important index that diagnose lung cancer. Main treatment means of notcellule lung cancer in later period is the chemotherapy of whole body.Monitoring of result under chemotherapy in lung cancer, study according toimage change at assess mainly at present, research has indicated for many yearsthat has certain meanings to jointly measure the tumor mark in diagnosis of lungcancer and curative effect of the judgement. The judgement of the result hasalready been generally acknowledged after the monitoring of CEA level is usedthe chemotherapy of lung cancer . It is suitable to jointly measure the standardnot to but does not find yet at present, accurate judgement curative effect fruitcomes.The multi-tumors sign protein examination is one kind of protein chip, thecollection of a body with micro electron, the micro machinery, the chemicalphysics technology, the computer technology. The analysis process continuouslymelts, integrated, the microminiaturized protein analysis technology, and hascharacteristic high velocity, high flux, high sensitivity and so on.Around this research use chemotherapy blood serum tumor marker multi-proteins examination, in examination blood serum 12 item of tumors markerlevel: Sugar chain protein CA19-9, CA242, CA125, CA15-3 neuron specificityenolase (neuron-specific enolase, NSE), cancer embryo antigen(carcinoembryonic antigen, CEA), the ferric albuminate iron albuminate(Ferritin), the human chorion presses the gonadotrophic hormone (humanchorionic gonadotrophin, HCG), the armor embryo protein (alpha -Fetoprotein,AFP), the prostate gland specificity antigen (prostate special antigen, PSA),Free-PSA, the human growth hormone (human growth hormone HGH),observes around its chemotherapy the change, the union thus makes thejudgment to the chemotherapy effect.Research technique:The research object is divided into 2 groups, the lung cancer group andhealthy Control group:1. The lung cancer group by observes tumor marker through the examinationchemotherapy in front of with the healthy group the difference which expressesin lung cancer and in the normal crowd.2. To the lung cancer group, after carries on 3 cyclical rules chemotherapy toend, chemotherapy around blood serum tumor marker comparison.3. Divides into the chemotherapy effective group and the invalid group thechemotherapy future trouble according to the phantom study change carries onthe comparison. Compares and pairs the t examination through the mean value.The main examination method, carries on the multi-tumors markerdetermination according to the according to the number Kang Sheng science andtechnology limited company multi-tumors marker protein chip diagnosissystem.Statistical analysisTo employs SPSS13.0 to count software package and carry on statisticalanalysis, examine t to the front and back patient's serum tumour mark thing levelof chemotherapy, the serum tumour mark thing level is compared with thehealthy crowd's serum level before chemotherapy. Mean value relativelyemploys analysis of variance.Findings:1. Lung cancer and healthy crowd's comparison. In front of the lung cancerpatient not good chemotherapy, the blood serum multi-tumors markercomparison, CA19-9, NSE, CEA, the CA242 healthy physical examinationadvances (P<0.05), CA125, CA153 then extremely advance (P<0.01).2. To the chemotherapy around the patient blood serum multi-tumors tracerinspection analysis, around the chemotherapy CA19-9, NSE, CA242, FER, HCG,CA125, CA153 have reduces, CA153, the NSE difference has statisticssignificance. (P<0.05).3. In changes according to the phantom study, reduces and the no change onetake changes into the chemotherapy effective group, the condition progresses asthe chemotherapy invalid group. To the chemotherapy effective chemotherapyaround two samples mean values comparative analysis, CEA, CA199, NSE,CA242, FER, f-PSA, PSA, CA125, CA153 have the varying degree reducing,NSE, CEA, CA242, the CA125 difference has the significance (P<0.05).4. In order to reduce the individual difference, carries on to the chemotherapyeffective patient blood serum multi-tumors marker protein level around pairsthe examination, finally demonstrated: NSE, CA242, CEA, CA125 compare infront of the chemotherapy obviously to reduce. The difference has statisticssignificance (P<0.05)Conclusion:Examine the multi-tumors marker protein jointly through the lung cancergroup and Control group, indicated obviously advances in the lung cancer grouptumor marker expression healthy crowd, therefore CA19-9, NSE, CEA, CA242,CA125, CA153 may take the diagnosis and the observation objective basis.Regarding the non-cellule lung cancer chemotherapy around, the bloodserum tumor marker change is not completely big, but regarding thechemotherapy effective group chemotherapy around the tumor marker changeby NSE, CEA, CA242, CA125 has the significance. In order to avoid theindividual difference, carries on pairs the examination to confirm similarly NSE,CA242, CEA, CA125 have the significance. Therefore NSE, CA242, CEA,CA125 regarding lung cancer chemotherapy around the curative effect judgmentand the prognosis estimated has the certain significance.