The Study Of The Biological Effect Of Pancrease Following Irradiation Of The Gastroenteric Tumor

Objective: To investingate the maximum tolerated radiation dose and the ralation of volum-time-effect of pancreaseMethods: 150 male mice , about 20±2g, were distributed in 5 groups randomly. Every mice received irradiation with ⁶⁰Co- γ to the epigastric zone.Irradiation doses of 2,4,6,8 Gy were given to Group B, C, D and E respectively. The animals were killed at 3,7,14,21,28,35,42,49 and 54 days after irradiation and microscopically and histologically examined, and blood glucose and serum alpha-amylase were determined. Results: The level of blood glucose of these test groups lower than the control after 7 days but higher than the control after 14 days (P<0.05) And the difference between each experiment was statistical significence (P<0.05) . The level of serum alpha-amylase between each experiment was also statistical significence (P<0.05) during 49 days. The pancrease of experiment begin to show pathological changes after 7days: degranulation, vacuolization, mitochondrial destruction, and interstitial fibrosis after 21days, Conclusions: The pathological changes of pancrease follow radiation like these of diabetic which to cue that radiation may initiation diabetic and the degree of changes is related to the dose of radiation and the time after radiation. The bigger of dose ,the graver of the chang and the longer of duration. The level of blood glucose is coincidence to the degree of pathological change ,so this is a good means to detect the of changes of pancrease which received irradiation to the epigastric zone.