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Risk Factors For Erectile Dysfunction In Diabetics

Posted on:2007-04-17Degree:MasterType:Thesis
Country:ChinaCandidate:D Z WangFull Text:PDF
GTID:2144360182491890Subject:Epidemiology and Health Statistics
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Objective: To identify risk factors for the development of Erectile Dysfunction(ED) in patients with diabetes mellitus.Methods: A hospital-based 1:1 pair-matched case control study was conducted in the Metabolic Disease Hospital of Tianjin Medical University during January 2005 to November 2005. Totally 116 pairs of age-matched (within 5 years) male diabetics were enrolled in this study. Patients were diagnosed for erectile dysfunction using the International Index of Erectile Function 5. All the information was collected by questionaire in face-to-face interview. Conditional logistic regression, principal component analysis, factor analysis and generalized relative risk model were used to analyse the risk factors and the potential interactions between some risk factors. Results: Results from univariate analysis showed that the following factors were significantly associated with the development of ED: longer duration of DM (OR=1.809, 95%CI: 1.229—2.664), higher fasting blood sugar when diagnosed firstly (OR=1.364, 95%CI: 1.062-1.752), higher level of HbA1c(OR=2.801, 95%CI: 1.083—7.246), treatment of DM (OR= 1.299, 95%CI: 1.004—1.680), diabetic peripheral neuropathy(OR=2.733, 95%CI: 1.513—4.938), higher level of urine protein (OR=1.600, 95%CI: 1.088—2.352), diabetic nephropathy (OR=2.353, 95%CI: 1.334-4.150), microvascular diseases (OR=2.200, 95%CI: 1.195-4.050), hypertension (OR=2.125, 95%CI: 1.173—3.850), higher level of SBP (OR=1.836, 95%CI: 1.308—2.577), family history of coronary heart disease (OR=2.364,95%CI: 1.168—4.783), higher blood pressure (OR=1.683, 95%CI: 1.178—2.404), anxiety(OR=L550,95%CI: 1.188—2.023), depression (OR=1.390,95%CI: 1.066—1.811), educational level (OR=0.421, 95%CI: 0.253—0.701) and the average personal income of each home per month (OR=0.690, 95%CI: 0.527—0.902). The analysis of generalized relative risk model showed that the various factors accord with multiplicative structure in general. The results of multivariate logistic analysis showed that the following factors were significantly associated with ED: family history of coronary heart disease (OR=2.503, 95%CI: 1.070—5.858), higher level of SBP (OR=1.738, 95%CI: 1.179—2.562), longer duration of DM (OR=1.539, 95%CI: 1.055—2.247), diabetic nephropathy (OR=2.082, 95%CI: 1.039—4.172), anxiety (OR=1.523, 95%CI: 1.133 — 2.047) and educational level (OR=0.308, 95%CI: 0.166—0.571). Besides the results mentioned above, the analysis of the interaction showed that the combined effects between risk factors trended towards supermultiplicative or midway structure.Conclusions: The development of ED in patients with diabetes mellitus was related to multiple factors. Longer duration of DM, hypertension, higher level of HbAic, diabetic peripheral neuropathy, diabetic nephropathy, family history of coronary heart disease, higher blood pressure and depression may increase the risk of development of ED while higher education may be a protective factors for ED in diabetic patients.
Keywords/Search Tags:Diabetes mellitus, Erectile Dysfunction, Risk factors, Case-control study, Logistic regression, Generalized relative risk model
PDF Full Text Request
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