| Objective and Method: Nitric oxide (NO), MBP and other related biological markers in cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and Guillain-Barre Syndrome (GBS) were detected to investigate the immunoregulation role of NO in the pathogenesis of inflammatory demyelinating diseases and to evaluate the clinical significance of NO.Result: (1) Levels of NO in CSF of MS group and GBS group (37.69±17.07 umol/L and 35.73± 14.17umol/L respectively) were higher than those of control group obviously (all p<0.01). (2) Levels of MBP in CSF of MS group and GBS group (57.20±3.97ug/L and 6.43±3.29ug/L respectively) were higher than those of control group obviously (all p<0.05). (3) Positive rates of oligoclone IgG band (IgG-OB) in MS group and GBS group were all significantly higher than control group (all P<0.01). (4) Correlation was found between NO and MBP in CSF with Perason test (p<0.05).Conclusion: (1) The increase of the NO levels in CSF of MS patients suggests that NO may involve in the autoimmunity pathogenesis of inflammatory demyelinating diseases and play a significant role as immuno effecter molecul in the loss of myelin and the damage of axon. (2) High level NO with positive immune competent cell and positive IgG-OB could reflect the activity of autoimmunologic reaction in CNS. (3) High level NO is a sign of immunoloregulation in patients of demyelinating diseases, which can modulate the interaction of all kinds of immunocytes and cytokine and limit the disease progress. (4) Correlation between NO and MBP in CSF suggests that the level of NO could reflect the activity of the diseases, and investigation of NO may be helpful to comprehend the patient's condition.
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