Expression Of Skp2 And Its Correlation With C-myc In Non-small Cell Lung Cancer

Objective: To study the expression of Skp2 ( S-phase kinase associated protein 2 ) and C-myc in non-small cell lung cancer and to investigate their relationship and clinical significance.Methods: The immunohistochemical stain method was used to detect the expression of Skp2 and C-myc in tissues samples of 42 cases non-small cell lung cancer , 10 benign lesions and 8 epithelial dysplasias. The MIAS-300 automatic image analysis instrument and HPIAS-2000 image analysis system were applied to scan and measure positive cells.Results: The average positive rate of Skp2 in lung cancer tissues was 24.83%± 13.64%, which was higher than that in benign lesion tissues(3.07% ± 1.32%, P <0.001) and also higher than dysplasia tissues(13.89%± 3.95%, P<0.05). The expression level of Skp2 was related to differentiation , TNM stages and lymphnode involvement , but not to pathological types. There was a positive relationship between Skp2 and C-myc ( r=0.448, P=0.003 ). Their coinstantaneous high expression rate was 38.1%( 16/42 ), which was related to TNM stages , but not to differentiation or pathological types or lymphnode involvement.Conclusions: 1) Over expression of Skp2 may relate with the carcinogenesis and progress of lung cancer. 2) Skp2 may cooperates with C-myc in the course of the carcinogenesis and progress of lung cancer.